With an average of four years of treatment on the ATAC study, hormone receptor-positive participants taking Arimidex were 22 percent more likely to be cancer-free than those taking tamoxifen patients on Arimidex vs. In addition, the absolute reduction of risk among those taking Arimidex compared to those taking tamoxifen increased from 1. These are small but important differences, and the most significant result is that the gap is increasing over time. Both drugs cause hot flashes, but unlike tamoxifen, Arimidex does not cause blood clots or increase the risk of uterine cancer.
However, there is a down side to being on Arimidex. Women taking this drug have more problems with bone fractures. Tamoxifen blocks estrogen in the breast, but it acts like a weak estrogen outside the breast, so it stimulates bone and keeps it from getting thin.
Arimidex, on the other hand, works by preventing the production of estrogen. If a woman has a history of osteoporosis, Arimidex may still be the best choice for her. I think that all women should have a bone density test before they start on Arimidex. I recommend Arimidex to most of my postmenopausal patients who have not yet started either drug.
Hawse, Thomas C. Spelsberg, and Matthew P. Journal of Clinical Oncology , Flockhart. Tamoxifen's selective estrogen activation effects can cause some serious side effects, including blood clots , stroke , and endometrial cancer. If you and your doctor are considering tamoxifen as part of your treatment plan, tell your doctor if you smoke or have a history of blood clots or heart attack. If you're taking tamoxifen, call your doctor immediately if you have any of these symptoms:. Hot flashes or night sweats from taking tamoxifen can be troubling.
But a British study suggests that women who experienced hot flashes and night sweats while taking hormonal therapy medicine were less likely to have the breast cancer come back recur. Knowing that this side effect might indicate a reduced risk of the cancer coming back may help some people stick with treatment despite the side effects. Some women on tamoxifen have reported memory problems while taking the medicine. While no definitive results are available yet, the ongoing Co-STAR Cognition in the Study of Tamoxifen and Raloxifene trial is looking at the effects tamoxifen and raloxifene have on memory and thinking.
While costs vary, tamoxifen is usually less expensive than an aromatase inhibitor because it is a generic medicine. If you have health insurance, check with your insurance company to see if and how much of the cost of tamoxifen is covered. If you don't have health insurance or your insurance doesn't cover the cost of tamoxifen, ask your doctor or nurse about programs in your area that may be able to help.
Soltamox is available to patients who qualify at the same co-pay cost as generic tamoxifen. You can also read Breastcancer. Create a profile for better recommendations. Breast implant illness BII is a term that some women and doctors use to refer to a wide range Frederick National Laboratory for Cancer Research.
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