New ways of administering GH are required because the use of a needle and syringe or a device where a patient still has to insert the needle manually into the skin on a daily basis can lead to low adherence and sub-optimal treatment outcomes.
The objective of this study was to assess the relative bioavailability of r-hGH Saizen, Merck Serono administered by a new needle-free device, cool. Methods: The study was performed with 38 healthy volunteers who underwent pituitary somatotrope cell down-regulation using somatostatin, according to a randomized, two-period, two-sequence crossover design.
Thus, it is important to follow the official instructions on how to administer growth hormone injections instead of ones you may find on the internet. The best place to inject HGH is in the fat tissue under the layers of your skin.
This type of injection is called subcutaneous and it ensures a great bioavailability for the medication. Besides, studies report that subcutaneous injections lead to a slower release of HGH in the body compared to other injection methods which more closely resembles a physiological growth hormone secretion. On the other hand, intramuscular injections lead to far too quick absorption. As evidence suggests, subcutaneous injections are also the easiest to perform at home , without the help of trained professionals.
The method allows for a broader range of suitable injection sites, a lower risk of infection, and less pain. According to small clinical trials, the abdominal area might lead to the best absorption of HGH compared to other subcutaneous injection sites. Nevertheless, injection sites need to be rotated frequently, because repeated subcutaneous injection on the same spot can lead to lipoatrophy.
This is a localized loss of fat that leads to the formation of a small dent in the skin. Lipoatrophy is a typical adverse effect for all kinds of subcutaneous injections and it can be completely avoided by rotating injection sites as studies show. There are different brands of HGH that your doctor may prescribe. They all contain bioidentical human growth hormone but often come in different pharmaceutical forms. Thus, brands may have different instructions for injecting depending on the exact form of the medication.
The optimal HGH dosage can also vary in-between different brands which should be taken into account to ensure the safety and effectiveness of your therapy. Some GH products come in powder form. They must be mixed and reconstituted with a diluent such as bacteriostatic water to become suitable for injection. For international customers we can not make shipping the needles together with HGH.
First and easy way , but needles on your local pharmacy, just tell for the staff in Pharmacy you need insulin needles - Ultra-Fine pen needles , either 29 gauge, 30 gauge or 31 gauge x 0,,8 mm or other brands with same size. Second way - we can shipping the needles to you separate for free , just you must to pay for shipping. We conclude that the GH injection pen is a reliable tool which seems to be more convenient for the patients.
Abstract We have evaluated the pharmacokinetics, reliability and patient tolerability of a newly developed injection pen for cartridged growth hormone GH. Publication types Comparative Study.
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